Dreamy Creamed Chicken and Biscuits Casserole Recipe for Cozy Nights
Southern comfort shines through this creamy chicken and biscuits casserole that promises pure, hearty satisfaction.
Tender chicken nestles in a rich, velvety sauce that whispers nostalgia with every bite.
Flaky golden biscuits crown this classic dish, creating a perfect harmony of textures and flavors.
Home cooks adore how easily this meal comes together, making weeknight dinners a breeze.
Warm, comforting, and absolutely delicious, this casserole delivers the kind of soul-soothing goodness that makes everyone gather around the table.
You’ll want seconds of this irresistible Southern-style classic that turns an ordinary meal into a memorable feast.
Quick Recipe Overview
Prep Time: 15 minutes
Cook Time: 35 minutes
Total Time: 50 minutes
Calories: 420 kcal
Servings: 7
Ingredients for Creamed Chicken and Biscuits Casserole
For Protein Base:
Cooked Chicken: Provides the hearty main protein, best when tender and freshly shredded from roasted or rotisserie chicken for maximum flavor.
Cheddar Cheese: Adds rich, melty goodness and creates a golden-brown topping with deep, tangy undertones.
For Creamy Binding:
Cream of Chicken Soup: Creates a silky, luxurious sauce that helps bind ingredients together with classic comfort food flavor.
Milk: Softens the soup and helps create a smooth, velvety texture throughout the casserole.
Mayonnaise: Introduces extra creaminess and subtle tanginess that enhances the overall richness.
For Flavor Boosters:
Onion: Brings a subtle aromatic sweetness and depth to the dish's overall flavor profile.
Roasted Red Pepper: Offers a sweet, slightly smoky note that brightens the casserole's taste.
Butter: Contributes a golden, rich undertone and helps achieve a beautiful surface color.
Refrigerated Biscuit Dough: Provides a quick, convenient topping that bakes into a perfectly golden, fluffy crust.
Tools to Make Creamed Chicken and Biscuits Casserole
Oven: Essential for baking the casserole to golden perfection.
Large skillet: Perfect for sautéing onions and creating flavor foundations.
Large mixing bowl: Ideal for combining chicken, soup, and other ingredients smoothly.
Baking dish: Necessary for assembling and baking the entire casserole.
Measuring spoons: Great for precise butter and ingredient measurements.
Cheese grater: Helps shred fresh cheddar cheese for melty topping.
Wooden spoon or spatula: Useful for mixing ingredients and spreading in the dish.
How to Assemble Creamed Chicken and Biscuits Casserole
Oven Preparation Kitchen warm-up. Preheat oven to 350°F and lightly grease a baking dish with butter or non-stick spray for easy serving and cleanup.
Onion Softening Base flavor builder. Gently sauté chopped onions in a skillet until they become translucent and release their sweet, subtle aroma.
Chicken Mixture Creation Flavor fusion. Combine sautéed onions with tender cooked chicken, creamy soup, smooth mayonnaise, rich milk, and vibrant roasted red peppers in a large mixing bowl.
First Baking Round Preliminary cooking. Spread the mixture evenly in the prepared baking dish and let it bake for 15 minutes, allowing flavors to meld and develop.
Cheesy Biscuit Topping Crowning glory. Sprinkle shredded cheddar cheese over the partially cooked mixture, then carefully arrange soft biscuit dough on top, finishing with an extra handful of cheese.
Final Bake Golden Perfection. Return the casserole to the oven and bake for an additional 20 minutes until biscuits turn a beautiful golden brown and cheese becomes gloriously melted.
Serving Moment Comfort on a plate. Let the casserole rest briefly before serving, creating a delightful meal that promises warmth and satisfaction.
Creamed Chicken and Biscuits Casserole Storage Tips
Smart Batch Cooking: Whip up two casseroles simultaneously and refrigerate the extra one for busy weeknights. Double the recipe and store the second dish in an airtight container for later enjoyment.
Fridge Fresh Strategy: Store leftover casserole in sealed containers within 2 hours of cooking. Refrigerated portions stay delicious for 3-4 days when kept at 40°F or lower, maintaining optimal taste and food safety.
Freezer-Friendly Technique: Wrap the casserole tightly in aluminum foil or freezer-safe containers before freezing. Uncooked or cooked versions can be stored for up to 2-3 months. Thaw overnight in the refrigerator before reheating.
Reheating Magic: Warm individual portions in the microwave for 1-2 minutes, or reheat the entire casserole in a 350°F oven for 15-20 minutes. Add a splash of milk to restore moisture and prevent dryness when reheating.
Tips to Tweak Creamed Chicken and Biscuits Casserole
Replace roasted red peppers with frozen mixed vegetables like peas, carrots, and corn for added nutrition and color burst.
Sprinkle fresh thyme, rosemary, or parsley into the chicken mixture to elevate the flavor profile and add a gourmet touch.
Experiment with different proteins like shredded turkey, diced ham, or even canned tuna as delicious chicken alternatives.
Try switching cheddar with pepper jack for a spicy kick or blend multiple cheese types like mozzarella and monterey jack for complex flavor depth.
Assemble the entire casserole up to 24 hours in advance, cover tightly with plastic wrap, and refrigerate. Remove from fridge 30 minutes before baking to ensure even cooking and perfect texture.
Serving Creamed Chicken and Biscuits Casserole Comfortably
Hearty Family Dinner Delight: Serve this creamy casserole as a comforting main course that'll have everyone asking for seconds.
Fresh Green Companion: Pair with a crisp mixed green salad topped with light vinaigrette to balance the rich, creamy chicken base and add a refreshing crunch.
Weekend Brunch Star: Transform this dish into a weekend brunch centerpiece by adding a few poached eggs on top and serving with fresh mimosas for a relaxed gathering.
Meal Prep Magic: Prepare the casserole ahead of time, refrigerate, and bake when ready – perfect for busy families looking for convenient, delicious dinner solutions that taste homemade.
Hearty Southern-style creamed chicken and biscuits casserole brings comfort to dinner tables with rich, creamy flavors. Home cooks will savor this classic dish that delivers warmth and satisfaction in each delicious bite.
Ingredients
Scale
2 lbs (907 g) cooked chicken, cut or shredded
1.5 cups (170 g) mild cheddar cheese, shredded
1 can cream of chicken soup
1 cup (240 ml) milk
0.5 cup (120 ml) mayonnaise
0.5 cup (75 g) roasted red pepper, chopped
1 small onion, chopped
1 tbsp (14 g) butter
1 can refrigerated biscuit dough
Instructions
Preparation: Preheat oven to 350°F (175°C) and thoroughly grease a 9×13-inch baking dish with non-stick spray or butter.
Sauté Foundation: In a skillet, melt butter and caramelize onions until translucent, developing a rich aromatic base for the casserole.
Combine Filling: Mix sautéed onions with shredded chicken, cream of chicken soup, mayonnaise, milk, and roasted red peppers in a large bowl, ensuring all ingredients are evenly distributed.
Initial Baking: Transfer the chicken mixture to the prepared baking dish and bake for 15 minutes to intensify flavors and create a bubbling foundation.
Cheese Layer: Remove from oven and sprinkle sharp cheddar cheese generously over the chicken mixture, creating a melty, golden surface.
Biscuit Topping: Arrange refrigerated biscuit dough across the cheese layer in a rustic, overlapping pattern, then dust with additional cheddar cheese for extra decadence.
Final Baking: Return casserole to oven and bake 18-22 minutes until biscuits are golden brown and cheese is completely melted.
Resting and Serving: Allow casserole to rest 5-7 minutes after baking, then serve warm alongside a crisp green salad to balance the rich, creamy texture.
Notes
Enhance Flavor Depth: Caramelize onions slowly to develop a rich, sweet undertone that elevates the entire casserole’s taste profile.
Prevent Soggy Biscuits: Place biscuit dough on top of the mixture just before baking to maintain a crispy, golden-brown texture.
Customize Protein Options: Swap shredded chicken with rotisserie chicken, turkey, or even cooked ham for versatile meal variations.
Cheese Melting Tip: Use freshly shredded sharp cheddar instead of pre-packaged cheese for superior melting and more intense flavor.
Founder, Head Recipe Developer & Cuisine Specialist
Expertise
Recipe Development and Testing, Modern American and European Cuisines, Food Styling and Photography, Culinary Education and Workshops
Education
Johnson & Wales University
Degree: Bachelor of Science in Culinary Arts
Focus: Comprehensive training in classical and modern cooking techniques, kitchen management, and global cuisines.
Auguste Escoffier School of Culinary Arts
Program: Diploma in Pastry Arts
Focus: Specialized education in baking and pastry, emphasizing artisanal bread, confections, and plated desserts.
Michael Reynolds is the founder and head recipe creator at wd-50.com. With over 15 years of experience in the kitchen, he’s spent time working in top restaurants and now focuses on making great food easy for everyone at home.
Michael studied culinary arts at Johnson & Wales University and later trained in pastry at the Auguste Escoffier School. He knows his way around both savory meals and sweet treats.
At wd-50.com, his goal is to help you feel confident in the kitchen, whether you’re trying something new or cooking a favorite dish. He loves using fresh ingredients and simple steps that still bring out big flavors.
Michael Reynolds
Founder, Head Recipe Developer & Cuisine Specialist
Expertise
Recipe Development and Testing, Modern American and European Cuisines, Food Styling and Photography, Culinary Education and Workshops
Education
Johnson & Wales University
Auguste Escoffier School of Culinary Arts
Michael Reynolds is the founder and head recipe creator at wd-50.com. With over 15 years of experience in the kitchen, he’s spent time working in top restaurants and now focuses on making great food easy for everyone at home.
Michael studied culinary arts at Johnson & Wales University and later trained in pastry at the Auguste Escoffier School. He knows his way around both savory meals and sweet treats.
At wd-50.com, his goal is to help you feel confident in the kitchen, whether you’re trying something new or cooking a favorite dish. He loves using fresh ingredients and simple steps that still bring out big flavors.